Table 2.
Association of alcohol consumption and mortality in breast cancer cases with ER-positive tumors
| Study | Alcohol intakea (U/wk) | N | Univariate
|
Multivariateb
|
||
|---|---|---|---|---|---|---|
| Events | HR (95% CI) | Events | HR (95% CI) | |||
| Overall mortality | ||||||
| SEARCH | ||||||
| Nondrinker | 1,273 | 218 | 1 (Ref.) | 180 | 1 (Ref.) | |
| ≤7 | 2,300 | 390 | 0.96 (0.82–1.14) | 332 | 1.02 (0.84–1.22) | |
| >7– ≤14 | 861 | 132 | 0.85 (0.68–1.05) | 112 | 0.90 (0.71–1.14) | |
| >14 | 396 | 56 | 0.77 (0.58–1.03) | 47 | 0.89 (0.64–1.23) | |
| Linear (per category) | 4,830 | 796 | 0.92 (0.85–0.99) | 671 | 0.95 (0.87–1.04) | |
| EPIC | ||||||
| Nondrinker | 807 | 87 | 1 (Ref.) | 50 | 1 (Ref.) | |
| ≤7 | 2,674 | 256 | 0.88 (0.69–1.14) | 119 | 1.08 (0.76–1.53) | |
| >7– ≤14 | 1,066 | 97 | 0.80 (0.59–1.08) | 43 | 0.92 (0.60–1.41) | |
| >14 | 1,206 | 116 | 0.83 (0.62–1.12) | 51 | 0.92 (0.61–1.39) | |
| Linear (per category) | 5,753 | 556 | 0.94 (0.86–1.03) | 263 | 0.95 (0.84–1.08) | |
| BCAC | ||||||
| Nondrinker | 2,209 | 423 | 1 (Ref.) | 219 | 1 (Ref.) | |
| ≤7 | 2,725 | 402 | 0.64 (0.54–0.75) | 313 | 0.56 (0.47–0.68) | |
| >7– ≤14 | 920 | 131 | 0.72 (0.59–0.88) | 79 | 0.68 (0.52–0.88) | |
| >14 | 982 | 147 | 0.74 (0.61–0.91) | 84 | 0.64 (0.49–0.83) | |
| Linear (per category) | 6,836 | 1,103 | 0.90 (0.84–0.95) | 695 | 0.85 (0.78–0.93) | |
| Breast cancer–specific mortality | ||||||
| SEARCH | ||||||
| Nondrinker | 1,273 | 158 | 1 (Ref.) | 131 | 1 (Ref.) | |
| ≤7 | 2,300 | 317 | 1.08 (0.89–1.31) | 274 | 1.15 (0.93–1.42) | |
| >7– ≤14 | 861 | 101 | 0.90 (0.70–1.15) | 84 | 0.94 (0.71–1.24) | |
| >14 | 396 | 47 | 0.90 (0.65–1.24) | 38 | 1.01 (0.70–1.46) | |
| Linear (per category) | 4,830 | 623 | 0.95 (0.87–1.04) | 527 | 0.98 (0.89–1.09) | |
| EPIC | ||||||
| Nondrinker | 807 | 45 | 1 (Ref.) | 24 | 1 (Ref.) | |
| ≤7 | 2,674 | 121 | 0.90 (0.62–1.29) | 52 | 1.33 (0.78–2.27) | |
| >7– ≤14 | 1,066 | 42 | 0.76 (0.49–1.19) | 17 | 1.18 (0.61–2.29) | |
| >14 | 1,206 | 46 | 0.76 (0.49–1.18) | 17 | 1.12 (0.57–2.17) | |
| Linear (per category) | 5,753 | 254 | 0.91 (0.79–1.04) | 110 | 1.01 (0.83–1.24) | |
| BCAC | ||||||
| Nondrinker | 2,209 | 203 | 1 (Ref.) | 74 | 1 (Ref.) | |
| ≤7 | 2,725 | 164 | 0.65 (0.51–0.83) | 116 | 0.58 (0.41–0.81) | |
| >7– ≤14 | 920 | 52 | 0.83 (0.61–1.14) | 22 | 0.97 (0.59–1.58) | |
| >14 | 982 | 53 | 0.84 (0.62–1.14) | 21 | 0.76 (0.46–1.26) | |
| Linear (per category) | 6,836 | 472 | 0.93 (0.84–1.02) | 233 | 0.92 (0.78–1.09) | |
a
SEARCH reported postdiagnosis alcohol consumption, whereas EPIC and BCAC reported prediagnosis alcohol consumption.
b
Adjusted for stage, grade, BMI, smoking status, SES, and menopausal status (EPIC estimates were also adjusted for country).