Table 3.
Association of alcohol consumption and mortality in patients with ER-negative tumors
| Study | Alcohol intakea (U/wk) | N | Univariate
|
Multivariateb
|
||
|---|---|---|---|---|---|---|
| Events | HR (95% CI) | Events | HR (95% CI) | |||
| Overall mortality | ||||||
| SEARCH | ||||||
| Nondrinker | 321 | 108 | 1 (Ref.) | 97 | 1 (Ref.) | |
| ≤7 | 529 | 147 | 0.75 (0.59–0.97) | 137 | 0.84 (0.64–1.09) | |
| >7– ≤14 | 187 | 30 | 0.43 (0.29–0.64) | 27 | 0.51 (0.33–0.78) | |
| >14 | 74 | 16 | 0.58 (0.34–0.98) | 13 | 0.54 (0.30–0.97) | |
| Linear (per category) | 1,111 | 301 | 0.74 (0.65–0.87) | 274 | 0.77 (0.66–0.90) | |
| EPIC | ||||||
| Nondrinker | 175 | 39 | 1 (Ref.) | 18 | 1 (Ref.) | |
| ≤7 | 739 | 154 | 0.74 (0.52–1.07) | 68 | 0.97 (0.56–1.67) | |
| >7– ≤14 | 240 | 46 | 0.65 (0.42–1.01) | 15 | 0.78 (0.38–1.60) | |
| >14 | 281 | 62 | 0.78 (0.51–1.20) | 31 | 1.11 (0.59–2.08) | |
| Linear (per category) | 1,435 | 301 | 0.94 (0.83–1.08) | 132 | 1.02 (0.85–1.25) | |
| BCAC | ||||||
| Nondrinker | 777 | 187 | 1 (Ref.) | 84 | 1 (Ref.) | |
| ≤7 | 772 | 192 | 0.96 (0.76–1.20) | 121 | 0.78 (0.57–1.06) | |
| >7– ≤14 | 295 | 73 | 0.97 (0.73–1.28) | 33 | 0.83 (0.55–1.26) | |
| >14 | 232 | 61 | 1.03 (0.76–1.38) | 30 | 0.87 (0.56–1.33) | |
| Linear (per category) | 2,076 | 513 | 1.00 (0.92–1.10) | 268 | 0.95 (0.82–1.09) | |
| Breast cancer–specific mortality | ||||||
| SEARCH | ||||||
| Nondrinker | 321 | 91 | 1 (Ref.) | 81 | 1 (Ref.) | |
| ≤7 | 529 | 127 | 0.78 (0.59–1.02) | 120 | 0.87 (0.66–1.16) | |
| >7– ≤14 | 187 | 28 | 0.48 (0.31–0.73) | 25 | 0.58 (0.37–0.92) | |
| >14 | 74 | 15 | 0.65 (0.38–1.12) | 12 | 0.60 (0.32–1.11) | |
| Linear (per category) | 1,111 | 261 | 0.78 (0.67–0.91) | 238 | 0.81 (0.69–0.96) | |
| EPIC | ||||||
| Nondrinker | 175 | 23 | 1 (Ref.) | 11 | 1 (Ref.) | |
| ≤7 | 739 | 93 | 0.70 (0.44–1.13) | 30 | 0.62 (0.29–1.32) | |
| >7– ≤14 | 240 | 23 | 0.52 (0.28–0.94) | 6 | 0.57 (0.20–1.64) | |
| >14 | 281 | 36 | 0.76 (0.43–1.33) | 17 | 1.30 (0.57–2.99) | |
| Linear (per category) | 1,435 | 175 | 0.93 (0.78–1.12) | 64 | 1.19 (0.90–1.56) | |
| BCAC | ||||||
| Nondrinker | 777 | 110 | 1 (Ref.) | 34 | 1 (Ref.) | |
| ≤7 | 772 | 111 | 1.05 (0.77–1.43) | 65 | 0.85 (0.53–1.37) | |
| >7– ≤14 | 295 | 31 | 0.82 (0.55–1.23) | 10 | 0.87 (0.42–1.80) | |
| >14 | 232 | 31 | 1.12 (0.75–1.68) | 13 | 1.05 (0.54–2.05) | |
| Linear (per category) | 2,076 | 283 | 1.00 (0.88–1.13) | 122 | 1.00 (0.80–1.24) | |
a
SEARCH reported postdiagnosis alcohol consumption, whereas EPIC and BCAC reported prediagnosis alcohol consumption.
b
Adjusted for stage, grade, BMI, smoking status, SES, and menopausal status (EPIC estimates were also adjusted for country).