Table 2. Simplified criteria for the diagnosis of autoimmune hepatitis.
| Variable | Cutoff | Points |
|---|---|---|
| ANA or SMA | ≥1:40 | 1 |
| ANA or SMA | ≥180 | 2a |
| Or anti-LKM-1 | ≥140 | |
| Or SLA | Positive | |
| IgG | >upper limite of normal | 1 |
| >1.10 times upper limit of normal | 2 | |
| Liver histology | Compatible with AIH | 1 |
| Typical of AIH | 2 | |
| Absence of viral hepatitis | Yes | 2 |
Score ≥6: probable AIH ≥7 definite AIH.
ANA, anti-nuclear antibody; SMA, anti-smooth muscle antibody; anti-LKM-1, anti-liver kidney microsomal antibody type 1; SLA, soluble liver antigen; IgG, immunoglobulin G; AIH, autoimmune hepatitis.
a
Addition of points achieved for all autoantibodies cannot exceed a maximum of 2 points.
Adapted from Hennes E.M. et al. 9