Table 3. Immunosuppressive treatment regimens for adults and children with autoimmune hepatitis.
Population | Initial regimen | Maintenance |
---|---|---|
Adults | Prednis(ol)one 60 mg/day Or Prednis(ol)one 30–60 mg/day in combination with azathioprine 1–2 mg/kg/day |
Prednis(ol)one 10 mg/week reduction until 20 mg/day, followed by of 5 mg/week reduction until 10 mg/day and by 2.5 mg/week reduction to reach maintenance (5 mg/day) Azathioprine 1–2 mg/kg/day if in combination with prednis(ol)one or 2 mg/kg/day if alone |
Children | Prednis(ol)one 2 mg/kg/daily (up to 60 mg/daily) decreased weekly if transaminase levels decrease. Azathioprine (1–2 mg/kg/day) added if transaminase levels plateau or increase. In the absence of jaundice, azathioprine can be started at the say time as prednisolone |
Prednis(ol)one tapered over 6–8 weeks to 0.1–0.2 mg/kg/day or 5 mg/day Azathioprine 1–2 mg/kg/day if needed or added initially |