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. 2015 Aug 12;34(1):81. doi: 10.1186/s13046-015-0199-5

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© Díaz-Carballo et al. 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Isobologram showing the in vitro interaction between amantadine and doxorubicin, cisplatin or 5FU in HCT8^WT and HCT8^RETO cells. Dose-response curves are based on the respective IC₅₀ values calculated after 24 hours of incubation. Amantadine-doxorubicin are synergistic in HCT8 ^WT/RETO (a & b). Amantadine-cisplatin are additive in HCT8 wildtype (c) and synergistic in HCT8^RETO (d). Amantadine-5FU are synergistic in RETO (f) but antagonistic in HCT8^WT (e). n = 3 independent experiments