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. 1988 Jan;7(1):29–35. doi: 10.1002/j.1460-2075.1988.tb02780.x

A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells.

P Chavrier 1, M Zerial 1, P Lemaire 1, J Almendral 1, R Bravo 1, P Charnay 1
PMCID: PMC454212  PMID: 3129290

Abstract

Zinc fingers are DNA-binding domains present in several eukaryotic regulatory proteins. We have identified a mouse gene, Krox-20, encoding a protein with three zinc fingers and whose expression is activated during G0/G1 transition in cultured cells. Serum stimulation of quiescent cells leads to rapid and transient accumulation of Krox-20 mRNA, with kinetics similar to those of the c-fos proto-oncogene. The induction does not require de-novo protein synthesis. In the mouse, Krox-20 is expressed at low levels in tissues which contain rapidly dividing cells. These properties suggest that Krox-20 encodes a transcription control factor, possibly involved in the modulation of cell proliferation.

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Selected References

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