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. Author manuscript; available in PMC: 2015 Aug 20.
Published in final edited form as: J Thromb Haemost. 2015 Mar 31;13(6):1073–1080. doi: 10.1111/jth.12876

Figure 1.

Figure 1

(a, b) Survival of wild type (FV+/+; dashed line), heterozygous (FVQ/+; solid line) and homozygous (FVQ/Q; stippled line) Leiden mice after intraperitoneal inoculation with S.aureus, or E.coli. (c, d) Bacterial abundance 1 h (IP: intraperitoneal lavage fluid) or 18 h after infection with S.aureus (c) or E.coli (d) in the indicated tissues were determined by dilution plating. Values are the average ± stdev. from triplicate measurements/organ from 5 mice/group. Asterisks indicate P<0.05 by pairwise comparison to wildtype mice by 2-tailed Student’s t-test. (e,f) In situ cell death detection by TUNEL staining of liver sections from 2 different wild type animals each, prepared 18 h after infection with S.aureus (e) or E.coli (f). Images were captured at 40× original magnification; bars indicate 100 μm.