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. 2015 Aug 19;10(8):e0136106. doi: 10.1371/journal.pone.0136106

Fig 6. The inhibitory effects of iron deficiency in ConA-induced hepatitis are independent from changes in gut microbiome and hepcidin levels.

Fig 6

(A) ALT serum levels (IU/mL) before, and 12 hours after the administration of ConA to mice fed for 3 weeks with an iron deficient (IrDef) or iron replete (IrRepl) diet, in the presence or absence of a 4-antibiotic (Atb) cocktail. (B) Relative expression of Hamp in liver tissue samples from mice receiving a 3 day-course of HPO CP28 (20 nmoles, daily) compared to control mice receiving PBS (p = 0.48). (C) ALT serum levels 12 hours after ConA challenge in mice treated with HPO CP28 or with PBS (p = 0.041). (D) ALT serum levels 12 hours after ConA challenge in mice pre-treated two hours before with a single intraperitoneal injection of 100μg of mouse hepcidin or sterile PBS (p = 0.84). Bar plots display mean and SEM.