Table 3.
Logistic regression analysis showing risk of excess offspring adiposity with maternal gestational OGTT glucose and GDM status
| Offspring |
||||
|---|---|---|---|---|
| BMI z score |
Sum of skinfolds ≥90th percentile (n = 1,310) | |||
| ≥85th percentile (n = 1,316) | ≥95th percentile (n = 1,316) | ≥99th percentile (n = 1,316) | ||
| FPG | ||||
| Unadjusted | 2.01 (1.37–2.96)† | 2.37 (1.41–3.98)‡ | 4.32 (2.07–9.04)† | 2.48 (1.44–4.26)‡ |
| Adjusted model* | 1.16 (0.76–1.76) | 1.34 (0.76–2.35) | 2.32 (1.05–5.13) | 1.61 (0.90–2.89) |
| 1-h PG unadjusted | 1.06 (0.98–1.15) | 1.01 (0.91–1.13) | 1.06 (0.90–1.24) | 1.02 (0.91–1.14) |
| 2-h PG unadjusted | 1.10 (0.99–1.23) | 0.99 (0.85–1.15) | 0.94 (0.75–1.18) | 0.99 (0.84–1.16) |
| AUC PG unadjusted | 1.06 (1.00–1.13) | 1.02 (0.93–1.11) | 1.04 (0.92–1.18) | 1.02 (0.93–1.12) |
| GDM | ||||
| Unadjusted | 1.62 (1.17–2.25)‡ | 1.56 (1.01–2.41) | 1.37 (0.72–2.63) | 1.30 (0.81–2.09) |
| Adjusted model* | 1.18 (0.84–1.67) | |||
Data are OR (95% CI) for one unit rise in OGTT glucose measures and for GDM (excluding unblinded participants) compared with no GDM. Sex-specific cutoffs were used for the sum of skinfolds ≥90th percentile.
*Adjusted for maternal OGTT BMI and offspring birth weight z score.
†P < 0.001.
‡P < 0.01.