Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jul 3;4(8):961–969. doi: 10.1242/bio.011189

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

PMC Copyright notice

Fig. 4. — Silibinin prevents TNF-α/IFN-γ (TI)-induced chromosomal instability (CIN) and sensitizes cells to TNF-α/IFN-γ (TI)-induced apoptosis. (A) HCT116 (left panel) and HepG2 (right panel) cells were grown in media containing TI or silibinin/TNF-α/IFN-γ for ten passages before karyotyping was performed. 45–55 cells were karyotyped. (B) The apoptosis profile of HCT116 (left panel) or HepG2 (right panel) was determined by FACS analyses using Annexin V-FITC apoptosis detection kit and by determining cleaved-PARP with western blot. All data shown are mean±s.e. ** denotes P<0.01, ***denotes P<0.001 compared with control cells; ^#denotes P<0.05, ^## denotes P<0.01 compared with silibinin treated cells only.