Figure 2.

Rescue of Adar1 Mutant Phenotypes in Adar1; Mavs Double-Mutant Mice and MEF Cultures

(A) Gross visceral anatomy of Adar1^−/−; Mavs^−/− newborn mice. (i) Appearance of pups at P0.5. (ii–vi) Sections showing general visceral anatomy (ii) with further detail of heart (iii), liver (iv), intestines (v), and rectum (vi). Scale bars in (i) and (ii), 3 mm and (iii)–(vi), 400 μm.

(B) ELISA showing mean levels of IFN-α and IL-6 in cell-culture supernatants of Adar1^+/+, Adar1^+/−, and Adar1^−/− MEFs with Mavs^+/+ or Mavs^−/− backgrounds following transfection with poly(I:C) (1 μg/ml; +) or water (−). The units on the y axis are expressed per 10,000 cells. Error bars, SD.