Figure 3.

Rescue of Adar1 Mutant Embryo Aberrant Proinflammatory Cytokine Expression in Adar1; Ifnar1 and Adar1; Mavs Double-Mutant Embryos

(A) Expression levels for an array of 12 ISGs measured in E11.5 whole embryos. For each gene, Adar1^−/−, Adar1^−/−; Ifnar1^−/−, and Adar1^−/−; Mavs values are expressed relative to wild-type, Ifnar1, or Mavs background levels, respectively (one on y axis, dashed lines). Error bars, SEM. ^∗p ≤ 0.05; ^∗∗p < 0.01; ^∗∗∗p < 0.001 versus wild-type; ††p < 0.01; †††p < 0.001 versus Adar1; ‡‡‡p < 0.001 versus Adar1^−/−; Ifnar1^−/−.

(B) Heatmap showing expression levels for an array of 96 proinflammatory cytokine and control transcripts measured in E11.5 whole embryos. For each gene, Adar1^−/−, Adar1^−/−; Ifnar1^−/−, and Adar1^−/−; Mavs^−/− values are expressed relative to wild-type, Ifnar1^−/−, or Mavs^−/− background levels, respectively, which are all zero following log₁₀-transformation and hence are not shown (white in color).