Figure 4.

Repetitive Element Expression in Adar1; Mavs Embryonic Mouse Liver

(A–C) Expression profiles of repetitive element classes (A), retrotransposon subfamilies (B), and specific LTR retrotransposon populations (C) in Adar1^−/−; Mavs^−/− E15.5 liver total RNA relative to Mavs^−/− (zero on x axis).

(D) Schematic of the prototypical mouse RLTR10C-flanked MMERVK10C retrotransposon (generated using Jurka et al., 2005). Positions and lengths of the gag, pro, pol, and env genes are shown. Black bars indicate qRT-PCR products (i–xi) generated using specific primer pairs (Table S4).

(E) Expression levels of RLTR10C-flanked MMERVK10C retrotransposon regions shown in (D) in Adar1^−/−; Mavs^−/−E15.5 livers relative to Mavs^−/− (one on y axis, dashed line).

Error bars, SEM. ^∗p ≤ 0.05; ^∗∗p ≤ 0.01; ^∗∗∗p ≤ 0.001 versus Mavs for each region.