TABLE 4.
Clinical disease stage scoringa
Time of scoring (mo p.i.) | Score for indicated animal |
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Orally inoculated group |
Aerosol-inoculated group |
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PO-1 | PO-2 | PO-3 | PO-4 | PO-5 | PO-6 | PO-7 | PO-8 | PO-9 | PO-10 | A-1 | A-2 | A-3 | A-4 | A-5 | A-6 | |
3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Termination of study | 3 | 3 | 3 | 3 | 0 | 2 | 2 | 3 | 3 | 2 | ||||||
16 | 0 | 0 | 0 | 0 | 0 | 0 | ||||||||||
19 | 1 | 1 | 1 | 1 | 2 | 3 | ||||||||||
20 | 2 | 1 | 2 | 1 | 2 | † | ||||||||||
21 | 2 | 2 | 2 | 1 | † | † | ||||||||||
22 | 2 | 2 | 2 | 1 | † | † | ||||||||||
23 | 2 | 3 | 3 | 2 | † | † | ||||||||||
25 | 2 | † | † | 3 | † | † | ||||||||||
26 | 3 | † | † | † | † | † |
Deer were given a score of 0 to 4 for clinical disease at each time point when excreta samples were taken. 0, normal behavior; 1, subtle behavioral changes (diurnal rhythms and patterns of sleeping, feeding, and activity are altered); 2, mild but observable neurological deficits, commonly mild ataxia in the hindquarters; 3, early stage, behavioral changes continue, with early signs of deterioration and continued progression of ataxia; 3, late stage, gait abnormalities become pronounced; 4, neurological deficit progression, wide-legged stance, low-hanging head, piloerection, obvious signs of muscle wasting, and increased ataxia. The appetite and ability to eat and drink are intact, with dramatic increases often seen (2 to 3 times normal volumes). †, deer that died during the study.