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. 2015 Aug 19;89(18):9581–9590. doi: 10.1128/JVI.01082-15

FIG 2.

FIG 2

Isotypes of FMDV-specific serum antibodies in FMD-vaccinated cattle before and after oronasal FMDV infection. Each line corresponds to a particular isotype, and each point represents the average ELISA titer obtained for all animals assayed. Titers are expressed as the highest dilution of the serum reaching an OD value equal to 0.2 (mean value from 25 negative sera ± 2 SD). The time point for the oronasal infection is indicated by a gray arrow. For comparative purposes, isotype profiles obtained from naïve infected animals (previously published [22]) are shown as dotted lines. Significant differences in mean antibody titers are the following: a and b, IgM > IgG1 and IgM > IgG2 (P < 0.0001 in both cases) at 7 dpv, respectively; c and e, IgG1 > IgM at 21 (P = 0.0024) and 29 dpv (P = 0.0089), respectively; d and f, IgG1 > IgG2 at 21 (P = 0.0004) and 29 dpv (P = 0.0089), respectively; g, IgM at 29 dpv > IgM at 1 dpi (P = 0.0017); h, IgG1 at 29 dpv > IgG1 at 1 dpi (P = 0.026).