TABLE 1.
Significant differences in FMDV-specific ASC mean numbers among immunoglobulin isotypes for each time point and organ assayed
| Tissue | Significant differences by time postvaccination (dpv) or -infectiona (dpi) |
||||||
|---|---|---|---|---|---|---|---|
| 7 dpv | 29 dpv | 2 dpi | 3 dpi | 4 dpi | 5 dpi | 6 dpi | |
| PSL | IgM > IgG1 (P < 0.001) (a) | IgG1 > IgM and IgG2 (P < 0.001) (b) | IgG1 > IgM, IgG2, and IgA (P < 0.001) (e); (f) IgM > IgA (P < 0.05) | IgG1 > IgM, IgG2 and IgA (P < 0.001) (g) | IgG1 > IgM and IgG2 (P < 0.05) (n); IgG1 > IgA (P < 0.001) (o) | IgG1 > IgG2 and IgA (P < 0.01) (r) | |
| ML | IgM > IgG1 and IgG2 (P < 0.05) (d) | ||||||
| MRL | IgM > IgG1, IgG2, and IgA (P < 0.001) (c) | IgG1 > IgM (P < 0.01) (s); IgG1 > IgG2 and IgA (P < 0.001) (s); IgM > IgG2 and IgA (P < 0.01) (u) | IgG1 > IgM, IgG2, and IgA (P < 0.001) (z); IgM and IgG2 > IgA (P < 0.001) (α) | ||||
| LRL | IgM > IgG1, IgG2, and IgA (P < 0.001) (c) | IgM > IgG1, IgG2 and IgA (P < 0.05) (h) | |||||
| PhT | IgM > IgG1, IgG2 and IgA (P < 0.001) (c) | IgM > IgG1 (P < 0.01) (i); IgM > IgG2 (P < 0.001) (j); IgM > IgA (P < 0.05) (k) | |||||
| TBL | IgG1 > IgM (P < 0.01) (l); IgG1 > IgG2 and IgA (P < 0.001) (m) | (p) IgG1 > IgG2 and IgA (P < 0.01) | IgG1 > IgM, IgG2, and IgA (P < 0.001) (v); IgM and IgG2 > IgA (P < 0.001) (w) | IgG1 > IgM, IgG2, and IgA (P < 0.001) (γ); IgM and IgG2 > IgA (P < 0.001) (β) | |||
| S | IgM > IgG1, IgG2, and IgA (P < 0.001) (c) | IgG1 > IgA (P < 0.01) (q) | IgM > IgG2 and IgA (P < 0.05) (x); IgG1 > IgM, IgG2, and IgA (P < 0.001) (y) | IgG1 > IgM, IgG2, and IgA (P < 0.001) (δ) | |||
a
Lowercase letters in parentheses refer to the significant differences denoted in Fig. 4.