TABLE 1.

Conditions during the aptamer selection process^a

Rounds	Aptamer concn (μM)	Capsid concn (nM)		Incubation time (min)		Vol of washing buffer (ml)
		WT capsids	Mutant capsids	WT capsids	Mutant capsids	Positive selection	Negative selection
1–3	110	14	6	60	30	1	1
4–6	110	6	10	60	30	1	1
7–9	55	6	10	30	60	2	0.4
10–13	27	0.2	14	15	60	2	0.4

^aThe volume of the binding reaction mixture was 100 μl.