Table 1.
Serum cytokine concentrations (pg/mL) in the two groups of non-small-cell lung cancer patients
| Events | Bone metastasis (n=30) | Non-bone metastasis (n=30) | P-value |
|---|---|---|---|
| Cytokines and chemokines | |||
| SDF-1 | 31.32±68.14 | 9.77±0.00 | 0.343 |
| Fractalkine | 9.77±0.00 | 13.52±11.84 | 0.343 |
| IP-10 | 1,975.97±1,090.68 | 1,452.32±1,006.17 | 0.279 |
| MCP-1 | 401.78±285.93 | 526.64±749.59 | 0.629 |
| IFNγ | 261.43±303.80 | 40.85±62.62 | 0.075 |
| IL-6 | 17.71±9.60 | 11.46±2.39 | 0.073 |
| IL-10 | 22.63±22.55 | 15.13±10.71 | 0.355 |
| IL-17α | 71.41±67.29 | 81.47±130.91 | 0.831 |
| IL-23 | 48.80±0.00 | 82.00±104.99 | 0.343 |
| Growth factors | |||
| PDGF-αα | 9,515.83±4,838.42 | 9,133.20±5,311.77 | 0.868 |
| FGF | 8.79±3.09 | 9.77±0.00 | 0.343 |
| IGFBP-3 | 3,991.17±2,160.96 | 1,744.93±1,473.94 | 0.014* |
| VEGF | 40.774±96.23 | 31.87±69.88 | 0.816 |
Notes: Data are presented as mean ± standard deviation.
*
P<0.05 compared with the group with non-bone metastasis.
Abbreviations: VEGF, vascular endothelial growth factor; PDGF-αα, platelet-derived growth factor-αα; IP-10, interferon-inducible protein 10; MCP-1, monocyte chemotactic protein-1; IFNγ, interferon γ; IL, interleukin; IGFBP-3, insulin-like growth factor binding protein-3; SDF-1, stromal cell-derived factor-1; FGF, fibroblast growth factor.