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. 2015 Apr 6;64(9):3321–3327. doi: 10.2337/db14-1790

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© 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

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Effect of GLP-1R agonists on CSM Ca²⁺ handling in MetS Ossabaw swine. A: Representative tracing of data from Ca²⁺ imaging protocol. Dashed line indicates baseline. B–D: Effect of chronic in vivo AC3174 treatment on CSM Ca²⁺ handling (Caf, caffeine; placebo, n = 4 swine; AC3174, n = 6 swine). B: Resting cytosolic Ca²⁺ levels. C: Caffeine-induced SR Ca²⁺ store release, corresponding to brackets in panel A. D: Undershoot of cytosolic Ca²⁺ levels below baseline, corresponding to black arrow in panel A. E and F: Effect of acute ex vivo exenatide treatment on Ca²⁺ handling in CSM from MetS Ossabaw swine (0 Ca, n = 38 CSM; exenatide [Exen], n = 24 CSM). E: Caffeine-induced SR Ca²⁺ store release, corresponding to brackets in panel A. F: Undershoot of cytosolic Ca²⁺ levels below baseline, corresponding to black arrow in panel A.