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. 2015 May 28;64(9):3203–3217. doi: 10.2337/db14-1938

Figure 3.

Figure 3

Islets from HFD-fed GPR43-deficient mice display reduced insulin secretion, and GPR43 agonists potentiate insulin secretion. A: Glucose-stimulated insulin secretion from isolated islets of WT and KO mice fed an NC diet and a 14-week HFD. Data are reported as the mean ± SEM of three independent experiments. B: Glucose- and GLP-1–stimulated insulin secretion from isolated islets of HFD-fed WT and KO mice. Data are reported as the mean ± SEM, n = 6 per group. Glucose-stimulated insulin secretion of primary isolated islets from NC diet–fed (C) and 14-week HFD-fed (D) WT and KO mice in the presence of 1 mmol/L acetate or 1 μmol/L PA. Data are reported as the mean ± SEM of three independent experiments. E: GSIS in GPR43, GPR41, or Gαq/11 siRNA-depleted Min6 cells. Data are reported as the mean ± SEM. F: GSIS in Min6 cells treated with 1 mmol/L acetate or 1 μmol/L PA for 48 h. G: GSIS in isolated human islets in the presence of 1 mmol/L acetate or 1 μmol/L PA. Data are reported as the mean ± SEM, n = 3. *P < 0.05.