Skip to main content
. 2015 May 28;64(9):3203–3217. doi: 10.2337/db14-1938

Figure 7.

Figure 7

GPR43 regulates expression of key β-cell genes. mRNA expression of β-cell genes in isolated islets from WT and KO mice fed an NC diet (A) and a 14-week HFD (B). Data are reported as the mean ± SEM, n = 6–8 per group. C: Intracellular insulin content of islets from WT and KO mice fed an NC diet (left panel) and an HFD (right panel). Data are reported as the mean ± SEM. D–I: The mRNA expression of β-cell genes in Min6 cells treated with acetate (1 mmol/L) or PA (1 μmol/L). A, acetate; C, control. D, F, and H: Min6 cells depleted of GPR43 or Gαq/11 by siRNA. E, G, and I: Min6 cells treated with MEK inhibitor (PD98059). Data are reported as the mean ± SEM of three independent experiments. J–L: The mRNA expression of β-cell genes in Min6 cells treated with PTX. Data are reported as the mean ± SEM of three independent experiments. *P < 0.05, treatment vs. control.