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. 2015 May 6;64(9):3111–3120. doi: 10.2337/db14-1627

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© 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

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HF feeding during pregnancy increased PPARγ expression in placentas, and PPARγ stimulated LPL expression in trophoblasts. A: Significantly increased PPARγ and C/EBPα protein levels were revealed in placentas of HF-fed dams (n = 7–8). *P < 0.05 vs. control. B and C: Overnight (13 h) treatment with the PPARγ agonist ROSI (10 μmol/L) robustly increased LPL expression and activities in confluent JEG-3 trophoblasts (n = 6). D: However, Ad-C/EBPα overexpression (24 h) did not alter LPL protein levels in JEG-3 trophoblasts (n = 6). Con, control; NS, not significant.