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. 2015 May 6;64(9):3081–3092. doi: 10.2337/db14-1810

Figure 3.

Figure 3

HF-fed SIRT3 KO mice have increased skeletal muscle insulin resistance. Rd in chow-fed (A) or HF-fed (C) WT and SIRT3 KO mice. The insulin-induced increase in Rd is the difference between clamp and basal Rd and represents the ability of insulin to stimulate peripheral tissue glucose uptake. Rg in gastrocnemius, vastus lateralis, soleus, diaphragm, and cardiac muscles is determined by the administration of nonmetabolizable glucose 2[14C]deoxyglucose in chow-fed (B) or HF-fed (D) WT and SIRT3 KO mice. 100gtiss, 100 g tissue. *P < 0.05; **P < 0.01.