Table 2.

Association of HIF3A SNP rs3826795 with measures of adiposity in the NHS and HPFS

	NHS		HPFS
	β ± SE	P value	β ± SE	P value
Weight at young age* (kg)	0.00 ± 0.19	0.86	−0.36 ± 0.29	0.21
Height (cm)	−0.21 ± 0.13	0.12	−0.10 ± 0.08	0.21
Weight at baseline (kg)	−0.09 ± 0.24	0.69	0.13 ± 0.33	0.69
BMI at baseline (kg/m2)	0.03 ± 0.08	0.71	0.03 ± 0.09	0.76
Weight at end point (kg)	0.06 ± 0.27	0.83	−0.01 ± 0.35	0.98
BMI at end point (kg/m2)	0.12 ± 0.11	0.18	−0.01 ± 0.10	0.93
BMI change (kg/m2)	0.04 ± 0.04	0.31	−0.05 ± 0.05	0.33
Weight change (kg)	0.07 ± 0.13	0.78	−0.13 ± 0.16	0.42
Waist circumference (cm)$	0.11 ± 0.11	0.32	0.01 ± 0.11	0.90

The linear regression model was used to test the association of DNA methylation variants with measures of adiposity after adjustment of age, source of genotyping data, smoking, alcohol intake, physical activity, total energy intake, television watching, and Alternate Healthy Eating Index. BMI change, changes in BMI from 1980 to 1990 in NHS and from 1986 to 1996 in HPFS; weight change, changes in body weight from 1980 to 1990 in NHS and from 1986 to 1996 in HPFS.

*Young age was defined as 18 years old in NHS and 21 years old in HPFS. Data were adjusted only for age and source of genotyping data.

$Waist circumference was assessed in 1986 in NHS and 1987 in HPFS.