Table 3.

Differences in 10-year changes in BMI per minor allele of rs3826795 according to baseline total intake of B vitamins among participants in NHS (1980–1990) and HPFS (1986–1996)

	Tertiles of total intake of B vitamins
Cohort$	T1	T2	T3	P value for interaction
Vitamin B2 (mg)
NHS	−0.10 ± 0.09	0.07 ± 0.09	0.22 ± 0.12	0.02
HPFS	−0.10 ± 0.09	−0.08 ± 0.08	0.06 ± 0.09	0.02
Pooled#	−0.10 ± 0.06	−0.01 ± 0.06	0.12 ± 0.07	0.004
Vitamin B6 (mg)
NHS	−0.01 ± 0.10	−0.01 ± 0.09	0.16 ± 0.11	0.14
HPFS	−0.08 ± 0.09	−0.09 ± 0.08	0.05 ± 0.09	0.18
Pooled	−0.05 ± 0.07	−0.06 ± 0.06	0.09 ± 0.07	0.18
Folate (μg)
NHS	0.11 ± 0.09	−0.08 ± 0.10	0.07 ± 0.10	0.11
HPFS	−0.10 ± 0.09	−0.12 ± 0.08	0.09 ± 0.09	0.03
Pooled	0.01 ± 0.06	−0.10 ± 0.06	0.08 ± 0.07	0.02
Vitamin B12 (μg)
NHS	0.00 ± 0.09	−0.10 ± 0.11	0.20 ± 0.10	0.003
HPFS	−0.20 ± 0.09	0.06 ± 0.08	0.01 ± 0.09	0.07
Pooled	−0.10 ± 0.06	0.01 ± 0.06	0.10 ± 0.07	0.002

Data are β-coefficients ± SE. Data on baseline total intake of B vitamins were assessed in 1980 (NHS) and 1986 (HPFS). Data on BMI were assessed in 1980 and 1990 in NHS and 1986 and 1996 in HPFS.

$The general linear model was used to test the genetic association of baseline total intake of B vitamins with 10-year changes in BMI after adjustment for age, source of genotyping data, smoking, alcohol intake, physical activity, total energy intake, Alternate Healthy Eating Index, television watching, baseline BMI, and other B vitamins (mutually adjusted).

#Results for the two cohorts were pooled by means of inverse variance–weighted fixed-effects meta-analyses.