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. 2015 Aug 20;5:13287. doi: 10.1038/srep13287

Figure 1. Representative cells and voltage-clamp recordings for VM and PCs.

Figure 1

Panel (A) Photomicrograph of isolated PC and VM; the green fluorescent cell expresses Cntn2-EGFP and represents a typical PC, and the cell without fluorescence represents a typical VM. Panels (B,C) Representative whole cell currents recorded for a step pulse (200 ms at −10 mV; pulse frequency, 0.5 Hz) from VMs (panel (B)) and PCs (panel (C), peak currents are off scale). Gray trace represents a control cell, and black trace represents a ΔKPQ cell. Panels (D,E) Bar graphs summarizing absolute magnitude of INaL (INa measured at 200 ms) normalized by cell capacitance. *p < 0.05 for WT vs ΔKPQ. WT-VM: N = 15, 5 animals; ΔKPQ-VM: N = 17, 5 animals; WT-PC: N = 15, 5 animals; ΔKPQ-PC: N = 23, 5 animals. WT: wild type, VM: ventricular myocyte, PC: Purkinje cell.