Table 3.

Synonyms for cytoplasmic patterns and association with specific antigens and diseases.

		Synonyms	Antigen associations	Disease association
Cytoplasmic patterns
	Fibrillar (AC-15,16,17)
	Linear/actin (AC-15)	Actin-like	Actin, non-muscle myosin	MCTD, chronic active hepatitis, liver cirrhosis, myasthenia gravis, Crohn’s disease, PBC, long-term hemodialysis, rare in SARD other than MCTD
	Filamentous/microtubules (AC-16)		Vimentin, cytokeratins	Infectious or inflammatory conditions, long-term hemodialysis, alcoholic liver disease, SARD, psoriasis, healthy controls
	Segmental (AC-17)		Alpha-actinin, vinculin, tropomyosin	Myasthenia gravis, Crohn’s disease, ulcerative colitis
	Speckled (AC-18–20)
	Discrete dots (AC-18)	GW body, processing body, lysosome*	GW182, Su/Ago2, Ge-1	PBC, SARD, neurological and autoimmune conditions
	Dense fine speckled (AC-19)	Homogeneous	PL-7, PL-12, ribosomal P proteins	“anti-synthetase syndrome,” PM/DM, SLE, juvenile SLE, neuropsychiatric SLE
	Fine speckled (AC-20)	Speckled	Jo-1/histidyl-tRNA synthetase	Anti-synthetase syndrome, PM/DM, limited SSc, idiopathic pleural effusion
	Reticular/AMA (AC-21)	Mitochondrion-like	PDC-E2/M2, BCOADC-E2, OGDC-E2, E1α subunit of PDC, E3BP/protein X	Common in PBC, SSc, rare in other SARD
	Polar/Golgi-like (AC-22)		Giantin/macrogolgin, golgin-95/GM130, golgin-160, golgin-97, golgin-245	Rare in SjS, SLE, RA, MCTD, GPA, idiopathic cerebellar ataxia, paraneoplastic cerebellar degeneration, viral infections
	Rods and rings (AC-23)		IMPDH2, others	HCV patients post-IFN/ribavirin therapy, rare in SLE, Hashimoto’s and healthy controls

These disease associations are primarily based on the antigens recognized by antibodies that reveal this particular ANA pattern. Amber background are recommended as competent-level reporting, whereas all others (Olive green) are considered for expert-level reporting.

*no molecular evidence to support this pattern is associated with lysosomal targets.