Table 4.
Synonyms for mitotic patterns and association with specific antigens and diseases.
| Synonyms | Antigen associations | Disease association | ||
|---|---|---|---|---|
| Mitotic patterns | ||||
| Centrosome (AC-24) | Centrioles | Pericentrin, ninein, Cep250, Cep110, enolase | Rare in SSc, Raynaud’s phenomenon, infections (viral and mycoplasma) | |
| Spindle fibers (AC-25) | MSA-2 | HsEg5 | Rare in SjS, SLE, other SARD | |
| NuMA-like (AC-26) | MSA-1 | Centrophilin | SjS, SLE, other | |
| Intercellular bridge (AC-27) | Stem body, midbody | Aurora kinase B, CENP-E, MSA-2, KIF-14, MKLP-1 | Rare in SSc, Raynaud’s phenomenon, malignancy | |
| Mitotic chromosome coat (AC-28) | Chromosome coat protein, dividing cell antigen, mitotic chromosome autoantigen (MCA) | Modified histone H3, MCA-1 | Rare in discoid lupus erythematosus, chronic lymphocytic leukemia, SjS, and polymyalgia rheumatica | |
These disease associations are primarily based on the antigens recognized by antibodies that reveal this particular ANA pattern.