Figure 1.

This schematic demonstrates the protective effect of enrichment against cognitive impairment in MS patients, whereby the negative relationship between cognitive status (y-axis) and MS disease burden (x-axis) is stronger among patients with lower enrichment (dashed line) relative to patients with higher enrichment (solid line). That is, higher enrichment attenuates the negative effect of MS disease burden on cognitive status. (Note that this schematic was not derived from actual data, but instead represents the typical pattern of results we have observed previously.)