Figure 4.

Roles of mitochondrial activity in C. albicans morphogenesis and biofilm formation. Mitochondrial activity is necessary for the transition from yeast to hyphal growth, but in mature biofilms mitochondria might be repressed perhaps due to changes in nutrients or access to oxygen. Reduction of mitochondrial activity might be driving protection from stresses, such as oxidative stress, thereby promoting cellular fitness. Whether and how mitochondrial functions impact on antifungal susceptibility of Candida biofilms remains to be determined.