Abstract
Food, like water, is in short supply in the desert. We report a specialized mechanism used by a desert mouse for surviving prolonged food shortages. The key element of this adaptation is a large reduction in resting metabolism. After about 2 weeks of restricted food intake (50% of normal), the desert mouse "switched down" its resting metabolism and was able to survive and maintain its weight indefinitely on these limited rations. When food was again freely available, resting metabolism "switched up," returning to normal levels in a single day. The reduced metabolism occurred without a decrease in body temperature or in levels of activity. In marked contrast, metabolism of the laboratory white mouse increased during food restriction, and the experiments had to be terminated to avoid starvation. We think this "metabolic switch" is common among desert mammals. It may be an amplification of a general metabolic response for coping with food scarcity common to all mammals, including humans.
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- Benson H., Malhotra M. S., Goldman R. F., Jacobs G. D., Hopkins P. J. Three case reports of the metabolic and electroencephalographic changes during advanced Buddhist meditation techniques. Behav Med. 1990 Summer;16(2):90–95. doi: 10.1080/08964289.1990.9934596. [DOI] [PubMed] [Google Scholar]
- Blank J. L., Desjardins C. Differential effects of food restriction on pituitary-testicular function in mice. Am J Physiol. 1985 Feb;248(2 Pt 2):R181–R189. doi: 10.1152/ajpregu.1985.248.2.R181. [DOI] [PubMed] [Google Scholar]
- CRAVEN C. W. Oxygen consumption of rat during partial inanition. Am J Physiol. 1951 Dec;167(3):617–620. doi: 10.1152/ajplegacy.1951.167.3.617. [DOI] [PubMed] [Google Scholar]
- Ferraris R. P., Diamond J. M. Specific regulation of intestinal nutrient transporters by their dietary substrates. Annu Rev Physiol. 1989;51:125–141. doi: 10.1146/annurev.ph.51.030189.001013. [DOI] [PubMed] [Google Scholar]
- Hulbert A. J., Dawson T. J. Standard metabolism and body temperature of perameloid marsupials from different environments. Comp Biochem Physiol A Comp Physiol. 1974 Feb 1;47(2):583–590. doi: 10.1016/0300-9629(74)90024-3. [DOI] [PubMed] [Google Scholar]
- Hulbert A. J., Else P. L. Comparison of the "mammal machine" and the "reptile machine": energy use and thyroid activity. Am J Physiol. 1981 Nov;241(5):R350–R356. doi: 10.1152/ajpregu.1981.241.5.R350. [DOI] [PubMed] [Google Scholar]
- Ma S. W., Foster D. O. Starvation-induced changes in metabolic rate, blood flow, and regional energy expenditure in rats. Can J Physiol Pharmacol. 1986 Sep;64(9):1252–1258. doi: 10.1139/y86-211. [DOI] [PubMed] [Google Scholar]
- Macmillen R. E. Aestivation in the cactus mouse, Peromyscus eremicus. Comp Biochem Physiol. 1965 Oct;16(2):227–248. doi: 10.1016/0010-406x(65)90062-9. [DOI] [PubMed] [Google Scholar]
- Margaria R. The sources of muscular energy. Sci Am. 1972 Mar;226(3):84–91. doi: 10.1038/scientificamerican0372-84. [DOI] [PubMed] [Google Scholar]
- McCarter R. J., McGee J. R. Transient reduction of metabolic rate by food restriction. Am J Physiol. 1989 Aug;257(2 Pt 1):E175–E179. doi: 10.1152/ajpendo.1989.257.2.E175. [DOI] [PubMed] [Google Scholar]
- Yousef M. K., Johnson H. D. Thyroid activity in desert rodents: a mechanism for lowered metabolic rate. Am J Physiol. 1975 Aug;229(2):427–431. doi: 10.1152/ajplegacy.1975.229.2.427. [DOI] [PubMed] [Google Scholar]
- Zhao M. J., Willis J. S. Reduced ion transport in erythrocytes of male Sprague-Dawley rats during starvation. J Nutr. 1988 Sep;118(9):1120–1127. doi: 10.1093/jn/118.9.1120. [DOI] [PubMed] [Google Scholar]