Table I.
Parameter | PPCOS-II (N = 750) |
PPCOS-I (N = 626) |
P-value* |
---|---|---|---|
Age | 28.9 ± 4.3 | 28.1 ± 4.0 | 0.001 |
Weight (kg) | 94.8 ± 26.3 | 94.3 ± 24.7 | 0.715 |
BMI (kg/m2) | 35.1 ± 9.3 | 35.2 ± 8.7 | 0.849 |
<30 | 245/750 (32.7) | 179/625 (28.6) | 0.057 |
30–34 | 127/750 (16.9) | 135/625 (21.6) | |
≥35 | 378/750 (50.4) | 311/625 (49.8) | |
Waist circumference (cm) | 105.9 ± 20.4 | 102.5 ± 19.6 | 0.002 |
Waist/hip ratio | 0.902 ± 0.103 | 0.864 ± 0.091 | <0.001 |
Hirsutism score | 17.0 ± 8.5 | 14.4 ± 7.9 | <0.001 |
<8 | 97/750 (12.9) | 121/626 (19.3) | <0.001 |
8–15 | 250/750 (33.3) | 262/626 (41.9) | |
≥16 | 403/750 (53.7) | 243/626 (38.8) | |
Race | <0.001 | ||
White | 590/750 (78.7) | 435/623 (69.8) | |
Black or African-American | 100/750 (13.3) | 109/623 (17.5) | |
Asian | 24/750 (3.2) | 17/623 (2.7) | |
American Indian or Alaska Native | 7/750 (0.9) | 72/623 (11.6) | |
Native Hawaiian or Pacific Islander | 2/750 (0.3) | 1/623 (0.2) | |
Mixed race | 27/750 (3.6) | ||
Ethnic group | <0.001 | ||
Not Hispanic or Latino | 622/750 (82.9) | 462/626 (73.8) | |
Hispanic or Latino | 128/750 (17.1) | 164/626 (26.2) | |
Length of attempting conception (months) | 41.7 ± 37.8 | 40.4 ± 35.8 | 0.503 |
Prior pregnancy | 273/750 (36.4) | 210/626 (33.6) | 0.269 |
Prior pregnancy loss | 174/750 (23.2) | 138/626 (22.0) | 0.610 |
Prior live birth | 148/750 (19.7) | 113/626 (18.1) | 0.428 |
History of smoking | 317/750 (42.3) | 247/626 (39.5) | 0.291 |
Total testosterone (ng/dl) | 55.0 ± 28.8 | 62.0 ± 28.6 | <0.001 |
Free androgen index | 7.8 ± 5.9 | 9.5 ± 6.7 | <0.001 |
Glucose (mg/dl) | 86.0 ± 12.6 | 89.0 ± 17.4 | <0.001 |
Insulin (µU/ml) | 19.3 ± 27.0 | 23.0 ± 26.6 | 0.011 |
Proinsulin (pmol/l) | 18.0 ± 14.4 | 24.9 ± 25.8 | <0.001 |
SHBG (nmol/l) | 33.9 ± 23.1 | 29.7 ± 18.1 | <0.001 |
White blood cells (103/µl) | 7.3 ± 1.9 | 7.3 ± 2.0 | 0.660 |
Data are presented as mean ± SD or frequencies (%). There are some missing values.
SHBG, sex hormone-binding globulin.
*Comparison for all patients between PPCOS-I and PPCOS-II studies.