Figure 1.

Pancreatic NETs after sunitinib therapy. At study initiation (06/19/2006), this patient had two pancreatic NETs (arrows) on CT scanning. Post-treatment scans (obtained 08/17/2006 and 11/14/2006) of tumors show a slight decrease in size and central necrosis. After the patient had completed the therapy regimen, scans (obtained 07/19/2007) show centripetal and centrifugal regrowth. Reinitiation of sunitinib therapy outside the bounds of the study resulted in redevelopment of central necrosis and a decrease in outside diameter (06/19/2008 and 10/19/2009). NETs, neuroendocrine tumors; CT, computed tomography.