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. 2015 Aug 11;8(2):75–92. doi: 10.1007/s12307-015-0170-1

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© The Author(s) 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — A In the CRPC II trial, median OS has not been achieved after 3 years, although 39 % of the patients did not show objective response (>50 % PSA response) to cellular therapy in situ. B Response in bone scan was observed in six of six patients. C Control of paraneoplastic lupus erythematosus was associated with objective tumor response. D Therapy response was on-going in six patients beyond stop of study medication (5 to 18 months) due to non-oncologic surgery. Following resistance to cellular therapy in situ, 60 % of the studied patients regained responsiveness against gonadotropin-releasing hormone (GnRH) agonists