Table 2.
Selecteda immune/inflammation markers that were significantly different between formaldehyde-exposed factory workers and non-exposed controls
| Median concentration (IQR), pg/ml | |||||||
|---|---|---|---|---|---|---|---|
| Marker | Controls (IQR) | FA-exposed (IQR) | % Change | P valueb | FDRc | P valued | FDRc |
| CXCL11 | 48.4 (39.9) | 36.2 (27.9) | −25.2 | 0.014 | 0.11 | 0.00080e | 0.030 |
| TARC (CCL17) | 75.0 (41.9) | 52.7 (39.6) | −29.7 | 0.0024 | 0.09 | 0.0028f | 0.053 |
| CRP | 3269100.0 (6632240.9) | 840617.6 (1398687.4) | −74.3 | 0.060 | 0.20 | 0.015g | 0.19 |
| TRAIL | 22.1 (14.5) | 12.0 (11.9) | −46.0 | 0.017 | 0.11 | 0.021h | 0.20 |
FA, formaldehyde; IQR, interquartile range.
a P value < 0.05 and FDR < 20%.
b P values were obtained from Wilcoxon rank sum tests comparing between exposed workers and controls.
cMultiple comparisons were controlled for with FDR using the Benjamini-Hochberg method.
d P values were obtained from linear regression models, adjusting for age, sex and (i) significant variables in univariate models or (ii) variables that change the coefficient of formaldehyde by at least 15%.
eModels adjusted for age, sex and alcohol consumption.
fModels adjusted for age, sex, smoking status and alcohol consumption.
gModels adjusted for age, sex, alcohol consumption and recent medication use.
hModels adjusted for age, sex and BMI.