FIG. 9.

DON-induced CCK and GLP-1 release by STC-1 cells are CaSR- and TRPA1-dependent. STC-1 cells grown in 24-well culture plate were preincubated with NPS 2143(10 µM), HC 030031(20 µM), and/or Calhex 231(20 µM) for 15 min as indicated. DON was then added to a concentration of 2 mM in the cultures incubated for 30 min and then the supernatants analyzed for CCK (A, C) and GLP-1 (B, D). Lower and upper case letters indicate significant difference with control or DON groups, respectively (P < .05). Results are representative of 3 independent experiments.