Table 5.
Factors Related to Severity of 1-Year Impairment Assessed by the Mattis Dementia Rating Scale
| Factor | No/Mild Dementia | Moderate/Severe Dementia | Univariate Factors |
Multivariate Factors |
||
|---|---|---|---|---|---|---|
| P Value* | OR (95% CI) | P Value* | OR (95% CI) | |||
| Randomized therapy | ||||||
| Placebo | 37 (55.2) | 4 (44.4) | .54 | 0.65 (.16–2.63) | .18 | 0.25 (.03–1.95) |
| VACV | 30 (44.8) | 5 (55.6) | ||||
| Age | ||||||
| Mean | 52.3 | 60.8 | .12 | .96 | .21 | 0.95 (.88–1.03) |
| SD | 15.2 | 10.4 | ||||
| Median | 53 | 59 | ||||
| Range | 14–80 | 47–73 | ||||
| Sex | ||||||
| Male | 36 (53.7) | 5 (55.6) | .92 | .93 | … | … |
| Female | 31 (46.3) | 4 (44.4) | ||||
| Baseline MDRS | ||||||
| Mean | 122.8 | 59.7 | <.001 | 1.05 | <.001 | 1.05 (1.02–1.08) |
| SD | 22 | 47.7 | ||||
| Median | 127.5 | 69 | ||||
| Range | 29–144 | 0–120 | ||||
| HSV symptom duration | ||||||
| Mean | 5.3 | 7.3 | .24 | .93 | … | … |
| SD | 4.5 | 6.8 | ||||
| Median | 4 | 4 | ||||
| Range | 0–28 | 1–23 | ||||
Data are presented as No. (%) unless otherwise specified.
Abbreviations: CI, confidence interval; HSV, herpes simplex encephalitis; MDRS, Mattis Dementia Rating Scale; OR, odds ratio; VACV, valacyclovir.
* P value by Wald χ2 test.