Table 2.
Response Adjusted for Duration of Antibiotic Risk Illustration: Participant Data and Data Summaries
| Participant | Treatment Arm | Overall Clinical Outcomea | Days of Antibiotic Use | DOOR | No. of Control Participants (n = 13) With a Lower DOOR |
|---|---|---|---|---|---|
| A | New | 2 | 5 | 11 | 9 |
| B | New | 1 | 3 | 1 | 13 |
| C | New | 1 | 4 | 2 | 13 |
| D | New | 2 | 4 | 10 | 9 |
| E | New | 3 | 3 | 19 | 4 |
| F | New | 2 | 3 | 9 | 9 |
| G | New | 3 | 5 | 21 | 4 |
| H | New | 3 | 4 | 20 | 4 |
| I | New | 1 | 7 | 5 | 12 |
| J | New | 3 | 8 | 23 | 3 |
| K | New | 2 | 6 | 12 | 9 |
| L | New | 1 | 5 | 3 | 13 |
| M | New | 2 | 8 | 14.5 | 7.5 |
| N | Control | 3 | 12 | 26 | Sum = 109.5 |
| O | Control | 2 | 7 | 13 | |
| P | Control | 1 | 9 | 7 | |
| Q | Control | 2 | 8 | 14.5 | |
| R | Control | 3 | 6 | 22 | |
| S | Control | 2 | 11 | 18 | |
| T | Control | 1 | 10 | 8 | |
| U | Control | 2 | 9 | 16 | |
| V | Control | 3 | 9 | 24 | |
| W | Control | 1 | 6 | 4 | |
| X | Control | 1 | 8 | 6 | |
| Y | Control | 2 | 10 | 17 | |
| Z | Control | 3 | 10 | 25 |
The probability of a better DOOR for a randomly selected participant from the new strategy compared with the old strategy is the number of between-treatment pairwise comparisons in which the new treatment has a higher DOOR than the control (109.5), divided by the total number of possible pairwise comparisons (169), resulting in 64.8% (95% confidence interval, 57%–71%).
Abbreviations: AE, adverse effects; DOOR, desirability of outcome ranking.
a Overall clinical outcome coding: 1, success without AE; 2, success with AE; 3, failure.