Table 2.
Virulence Genes Among Escherichia coli Strains From Fecal Samples of 6 Household Members as Obtained on 3 Different Samplings Over 19 Weeks
| Virulence Geneb,c | Presence or Absence of Virulence Genea |
|||||||
|---|---|---|---|---|---|---|---|---|
| ST131 |
Non-ST131 |
|||||||
| 903 (n = 15) | 1908 (n = 3) | 583 (n = 3) | 1701 (n = 6) | 1835 (n = 3) | 1836 (n = 2) | 1837 (n = 4) | 1924 (n = 2) | |
| Adhesins | ||||||||
| papAHCG | + | − | − | + | − | + | − | − |
| papEF | + | − | + | + | − | + | − | − |
| papG II | + | − | − | + | − | − | − | − |
| papG III | − | − | − | − | − | + | − | − |
| sfa/focDE | − | − | − | − | − | + | − | − |
| focG | − | − | − | − | − | + | − | − |
| afa/draBC | − | − | + | − | − | − | − | − |
| iha | + | − | + | − | − | − | − | − |
| fimH | + | + | + | + | + | + | + | + |
| hra | + | + | − | − | − | + | − | − |
| Toxins | ||||||||
| hlyD | + | − | − | − | − | + | − | − |
| cnf1 | − | − | − | − | − | + | − | − |
| sat | + | + | + | + | + | + | + | + |
| pic | − | − | − | − | − | + | − | − |
| vat | − | − | − | + | − | + | − | − |
| Siderophores | ||||||||
| iroN | − | − | − | − | − | + | − | − |
| fyuA | + | + | + | + | − | + | − | − |
| ireA | − | − | − | + | − | + | − | − |
| iutA | + | + | + | − | − | − | − | − |
| Protectins | ||||||||
| kpsM II | + | − | + | + | − | + | − | − |
| K1 | − | − | + | + | − | − | − | − |
| K5 | + | − | − | − | − | − | − | − |
| traT | + | + | − | + | + | − | − | − |
| Miscellaneous | ||||||||
| usp | + | − | − | + | − | + | − | − |
| ompT | − | − | − | + | − | + | + | − |
| H7 fliC | − | − | − | + | − | − | − | − |
| malX | + | − | − | + | − | + | − | − |
| clbB, clbN | − | − | − | + | − | − | − | − |
Abbreviation: ST, sequence type.
a Plus sign, gene present in ≥50% of isolates of strain. Minus sign, gene present in <50% of isolates of strain.
b Genes listed are those detected in ≥1 isolate. Definitions: papAHCG, papEF, papG II, and pap G III (P fimbriae structural subunits, assembly, and tip adhesion variants), sfa/focDE (S and F1C fimbriae), focG (F1C fimbriae adhesion), afa/draBC (Dr-binding adhesins), iha (adhesin-siderophore receptor), fimH (type 1 fimbriae adhesin), hra (heat-resistant agglutinin), hlyD (alpha hemolysin), cnf1 (cytotoxic necrotizing factor), sat (secreted auto-transporter toxin), pic (protein associated with intestinal colonization), vat (vacuolating toxin), iroN (salmochelin receptor), fyuA (yersiniabactin receptor), ireA (siderophore receptor), iutA (aerobactin receptor), kpsM ll (group 2 capsules), K1 (group 2 capsule variant), K5 (group 2 capsule variant), traT (serum resistance-associated), usp (uropathogenic-specific protein), ompT (outer membrane protease), H7 fliC (flagellar variant), malX (pathogenicity island marker), clbB and clbN (colibactin polyketide synthesis).
c Genes sought but not detected: papG allele I (variant P adhesin), sfaS (S fimbriae adhesin), afaE8 (variant afimbrial adhesin), bmaE (M fimbriae), gafD (G fimbriae), F17 (adhesin variant), clpG (adhesin variant), hlyF (variant hemolysin), cdtB (cytolethal distending toxin), tsh (temperature-sensitive hemagglutinin), astA (toxin of enteroaggregative Escherichia coli), kpsMT III (group 3 capsule), K15 (capsule variant), K2/K100 (capsule variant), rfc (O4 lipopolysaccharide synthesis), cvaC (microcin V), ibeA (invasion of brain endothelium), and iss (increased serum survival).