Table 3.

Frequency of Antifolate Resistance Mutations in Infants Unexposed or Exposed to Cotrimoxazole Preventive Therapy

Resistance Mutation	Replicate 1	Replicate 2	Mean	SD	P Valuea
dhfr N51I
CPT unexposed	98.6	97.4	98.0	0.8	.1
CPT exposed	99.5	99.4	99.5	0.1
dhfr C59R
CPT unexposed	96.6	96.5	96.6	0.1	.6
CPT exposed	96.0	96.7	96.4	0.5
dhfr S108N
CPT unexposed	99.7	99.6	99.7	0.1	.04
CPT exposed	99.9	99.9	99.9	0.0
No. of reads
dhfr	35 211	22 573	28 892	8936
dhps	17 885	20 400	19 143	1778

Abbreviations: CPT, cotrimoxazole preventive therapy; dhfr, dihydrofolate reductase; dhps, dihydropteroate synthetase; SD, standard deviation.

^a P value based on an unpaired t test.