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Stepwise sampling approach to narrow down the early disease mechanisms in this high-risk sample. Starting with a 20-year follow-up of 48 densely affected multigenerational families (1500 clinically characterized adult members), we identified 405 members affected by a DSM-IV schizophrenia or bipolar disorder (BD). We included 66 high-risk offspring aged 7–22 years who met our inclusion criteria.
