Fig. 2. Calculation of mean amplitude of glucose excursion (MAGE). In the first step, all the local maximum/minimum values are determined. The next step is an assessment of maximum/minimum pairs against the standard deviation (SD). If the difference from minimum to maximum is greater than the SD, this variation from mean measure is retained. If the local maximum/minimum is less than 1 SD it is excluded from further calculations. These troughs are retained and summed to achieve the MAGE.
