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. Author manuscript; available in PMC: 2015 Aug 21.
Published in final edited form as: Nat Commun. 2013;4:1816. doi: 10.1038/ncomms2828

Figure 3. Mutant polyQ proteins interact with TERA/VCP/p97 in the human brain.

Figure 3

(a) Mutant polyQ proteins and VCP are colocalized in inclusion bodies of human patients with polyQ diseases. Subcellular distribution of VCP was remarkably changed in neurons possessing aggregates of polyQ disease proteins. Scale bar represents 10 μm. In control human brains, subcellular accumulation or foci of TERA/VCP/p97 was not observed (Supplementary Fig. S6).

(b) Coprecipitation of mutant polyQ and VCP proteins from mutant polyQ-KI mouse brain samples.