Clodronate pretreatment decreased volumes for pressure changes in mechanically ventilated mice following LC. Uninjured controls are shown in open triangles, Liposome-pretreated animals are shown in solid triangles and clodronate-pretreated animals are in solid boxes. “Quasi-static” closed-chest P/V curves were measured at 5, 24, 48, and 72 hours after injury. Each curve was generated by more than 4,000 data points for each animal, and SEM for nine animals is not shown to allow clear visualization of the curves.