Table 3. Associations between genus-specific HPV seroreactivity and SCC cases and controls.
| HPV genus | Controls (N = 300) n (%) |
SCC (N = 173) | Pb | |
|---|---|---|---|---|
|
| ||||
| n (%) | OR (95% CI)a | |||
| Alpha | ||||
| Seronegative | 194 (64.7) | 108 (62.4) | 1.00 (reference) | ref. |
| Seropositive | 106 (35.3) | 65 (37.6) | 1.11 (0.72–1.71) | 0.64 |
| 1 HPV type | 59 (19.7) | 30 (17.3) | 0.91 (0.52–1.59) | 0.75 |
| ≥2 HPV types | 47 (15.7) | 35 (20.2) | 1.35 (0.77–2.34) | 0.29 |
| Ptrend = 0.39 | ||||
| Beta | ||||
| Seronegative | 119 (39.7) | 46 (26.6) | 1.00 (reference) | ref. |
| Seropositive | 181 (60.3) | 127 (73.4) | 1.93 (1.23–3.02) | 0.004 |
| 1 HPV type | 47 (15.7) | 32 (18.5) | 1.88 (1.01–3.49) | 0.05 |
| 2–3 HPV types | 51 (17.0) | 32 (18.5) | 1.93 (1.04–3.58) | 0.04 |
| 4–8 HPV types | 36 (12.0) | 29 (16.8) | 2.50 (1.30–4.83) | 0.006 |
| >8 HPV types | 47 (15.7) | 34 (19.7) | 1.60 (0.86–3.00) | 0.14 |
| Ptrend = 0.04 | ||||
| Gamma | ||||
| Seronegative | 145 (48.3) | 66 (38.2) | 1.00 (reference) | ref. |
| Seropositive | 155 (51.7) | 107 (61.9) | 1.34 (0.88–2.04) | 0.17 |
| 1 HPV type | 63 (21.0) | 43 (23.7) | 1.17 (0.68–2.00) | 0.58 |
| ≥2 HPV types | 92 (30.7) | 66 (38.2) | 1.47 (0.92–2.36) | 0.11 |
| Ptrend = 0.11 | ||||
| Mu | ||||
| Seronegative | 204 (68.0) | 107 (61.9) | 1.00 (reference) | ref. |
| Seropositive | 96 (32.0) | 66 (38.2) | 1.41 (0.91–2.18) | 0.13 |
| Nu | ||||
| Seronegative | 266 (88.7) | 152 (87.9) | 1.00 (reference) | ref. |
| Seropositive | 34 (11.3) | 21 (12.1) | 0.91 (0.48–1.74) | 0.78 |
| Control antigens | ||||
| JCV | ||||
| Seronegative | 108 (36.0) | 45 (66.0) | 1.00 (reference) | ref. |
| Seropositive | 192 (64.0) | 128 (74.0) | 1.40 (0.89–2.20) | 0.15 |
| KIV | ||||
| Seronegative | 24 (8.0) | 12 (6.9) | 1.00 (reference) | ref. |
| Seropositive | 276 (92.0) | 161 (93.1) | 0.78 (0.34–1.75) | 0.54 |
NOTE: The ORs and 95% CIs for the associations between genus-specific HPV seroreactivity and SCC, along with the P value for trend for SCC risk associated with seropositivity to an increasing number of HPV types within a given genus. In addition, for comparison purposes, the ORs and 95% CIs for the associations between 2 human polyomaviruses (JCV and KIV) and SCC are also presented.
a
OR and 95% CI adjusted for age and sex.
b
P value for β-coefficient corresponding to HPV term in logistic regression model.