Table 5. Association between genus-β type–specific HPV seropositivity and SCC, stratified by HPV DNA status of the same HPV type in the tumor.
| Beta (β) Species/typea | Controls (N = 300) n (%) |
SCC HPV type-specific DNA status | |||
|---|---|---|---|---|---|
|
| |||||
| Positive (N = 96) | Negative (N = 50) | ||||
|
|
|
||||
| n (%) | OR (95% CI)b | n (%) | ORb (95% CI)b | ||
| β1 | |||||
| HPV 5 | |||||
| Seronegative | 262 (87.3) | 13 (61.9) | 1.00 (reference) | 44 (88.0) | 1.00 (reference) |
| Seropositive | 38 (12.7) | 8 (38.1) | 3.48 (1.27–9.59) | 6 (12.0) | 0.87 (0.34–2.25) |
| HPV 8 | |||||
| Seronegative | 231 (77.0) | 10 (58.8) | 1.00 (reference) | 36 (72.0) | 1.00 (reference) |
| Seropositive | 69 (23.0) | 7 (41.2) | 2.04 (0.69–6.01) | 14 (28.0) | 1.26 (0.63–2.53) |
| HPV 20 | |||||
| Seronegative | 237 (79.0) | 6 (54.5) | 1.00 (reference) | 46 (92.0) | 1.00 (reference) |
| Seropositive | 63 (21.0) | 5 (45.5) | 2.74 (0.77–9.74) | 4 (8.0) | 0.31 (0.11–0.91) |
| HPV 24 | |||||
| Seronegative | 263 (87.7) | 11 (61.1) | 1.00 (reference) | 48 (96.0) | 1.00 (reference) |
| Seropositive | 37 (12.3) | 7 (38.9) | 3.79 (1.24–11.5) | 2 (4.0) | 0.24 (0.05–1.08) |
| HPV 36 | |||||
| Seronegative | 248 (82.7) | 10 (55.6) | 1.00 (reference) | 46 (92.0) | 1.00 (reference) |
| Seropositive | 52 (17.3) | 8 (44.4) | 2.63 (0.92–7.50) | 4 (8.0) | 0.32 (0.11–0.96) |
| β2 | |||||
| HPV 9 | |||||
| Seronegative | 225 (75.0) | 7 (87.5) | 1.00 (reference) | 46 (92.0) | 1.00 (reference) |
| Seropositive | 75 (25.0) | 1 (12.5) | 0.31 (0.04–2.72) | 4 (8.0) | 0.24 (0.08–0.70) |
| HPV 15 | |||||
| Seronegative | 224 (74.7) | 7 (50.0) | 1.00 (reference) | 46 (92.0) | 1.00 (reference) |
| Seropositive | 76 (25.3) | 7 (50.0) | 2.55 (0.81–8.01) | 4 (8.0) | 0.23 (0.08–0.66) |
| HPV 17 | |||||
| Seronegative | 223 (74.3) | 10 (45.5) | 1.00 (reference) | 41 (82.0) | 1.00 (reference) |
| Seropositive | 77 (25.7) | 12 (54.5) | 3.36 (1.29–8.72) | 9 (18.0) | 0.68 (0.31–1.49) |
| HPV 23 | |||||
| Seronegative | 239 (79.7) | 30 (76.9) | 1.00 (reference) | 46 (92.0) | 1.00 (reference) |
| Seropositive | 61 (20.3) | 9 (23.1) | 1.26 (0.54–2.94) | 4 (8.0) | 0.36 (0.12–1.07) |
| HPV 38 | |||||
| Seronegative | 226 (75.3) | 17 (65.4) | 1.00 (reference) | 47 (94.0) | 1.00 (reference) |
| Seropositive | 74 (24.7) | 9 (34.6) | 1.36 (0.55–3.38) | 3 (6.0) | 0.20 (0.06–0.67) |
| β3 | |||||
| HPV 75 | |||||
| Seronegative | 254 (84.7) | 4 (80.0) | 1.00 (reference) | 49 (98.0) | 1.00 (reference) |
| Seropositive | 46 (15.3) | 1 (20.0) | 1.27 (0.14–12.0) | 1 (2.0) | 0.11 (0.01–0.80) |
| β4 | |||||
| HPV 92 | |||||
| Seronegative | 250 (83.3) | 7 (77.8) | 1.00 (reference) | 45 (90.0) | 1.00 (reference) |
| Seropositive | 50 (16.7) | 2 (22.2) | 1.27 (0.24–6.65) | 5 (10.0) | 0.56 (0.21–1.51) |
| β5 | |||||
| HPV 96 | |||||
| Seronegative | 255 (85.0) | 4 (57.1) | 1.00 (reference) | 46 (92.0) | 1.00 (reference) |
| Seropositive | 45 (15.0) | 3 (42.9) | 3.47 (0.72–16.6) | 4 (8.0) | 0.42 (0.14–1.28) |
NOTE: The ORs and 95% CIs for the associations between genus-β type–specific HPV seropositivity and SCC, stratified by the presence of HPV DNA to the same genus-beta type in the SCC tumor tissue itself.
a
No tumor specimens were DNA positive for HPV 76. Therefore, concordance analyses were not conducted for HPV 76.
b
OR and 95% CI adjusted for age and sex.