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The scheme of NOX2β protein. NOX2β is a novel splicing variant of NOX2 isoform. p47-BS indicates the conserved binding sites of p47phox (63). The NOX2β variant lacks several regions binding prosthetic groups. These are four conserved histidine residues that are postulated to bind two Fe-heme complexes and which are involved in the electron transfer from NADPH to molecular oxygen.
