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. 2015 Aug 10;23(5):428–445. doi: 10.1089/ars.2013.5783

FIG. 7.

FIG. 7.

NADPH oxidase activation via PI3K. Ligand binding to fMLP receptors triggers phosphatidylinositol 3-kinase (PI3K) activation and subsequent phosphatidylinositol 3,4,5-triphosphate (PIP3) production. PIP3 induces protein-dependent kinase (PDK) activation, and PDK, in turn, phosphorylates and activates Akt. Phospholipase Cc2 (PLCc2) is directly activated by PIP3 and leads to the activation of diacylglycerol (DG)-dependent protein kinases C, cPKC, and PKCd. The activation of these PKCs results in p47phox phosphorylation and the subsequent NADPH oxidase activation (172). fMLP, formyl-methionyl-leucyl-phenylalanine.