Table 3.
Biochemical characteristics of patients from four groups according to the stage of CKD and EmLV
| Parameter | Early stage CKD without LVDD (n = 33) | Early stage CKD with LVDD (n = 16) | Advanced stage CKD without LVDD (n = 10) | Advanced stage CKD with LVDD (n = 14) | p < 0.05 |
|---|---|---|---|---|---|
| Age (years) | 64.4 ± 13.1 | 69.8 ± 10.3 | 65.2 ± 13.6 | 69.5 ± 15.8 | – |
| BMI (kg/m2) | 29.1 ± 5.5 | 29.6 ± 6.2 | 27.1 ± 3.1 | 26.7 ± 3.7 | – |
| Creatinine (mg/dL) | 1.1 (0.7–2.0) | 1.2 (0.7–1.5) | 3.2 (1.6–4.3) | 3.0 (2.0–6.3) | 1–3, 1–4, 2–3, 2–4 |
| eGFR (ml/min/1.73 m2) | 52 (31–85) | 56 (35–79) | 16 (10–30) | 21 (6–29) | 1–3, 1–4, 2–3, 2–4 |
| Urea (mg/dL) | 47 (19–74) | 44 (29–62) | 101 (68–204) | 120 (53–163) | 1–3, 1–4, 2–3, 2–4 |
| PTH (pg/ml) | 48 (24–107) | 50 (30–85) | 175 (64–408) | 157 (66–346) | 1–3, 1–4, 2–3, 2–4 |
| NT–proBNP (pg/ml) | 96 (12–549) | 191 (35–643) | 520 (65–966) | 518 (46–4,968) | 1–3, 1–4, 2–4 |
| Hb (g/dL) | 13.4 ± 1.3 | 13.5 ± 1.7 | 10.6 ± 1.6 | 12.0 ± 1.8 | 1–3, 2–3, 2–4 |
| HT (%) | 39 (13–46) | 41 (13–49) | 35 (26–38) | 36 (13–43) | 1–3, 2–3 |
| PLT (103/uL) | 225 (66–453) | 219 (45–334) | 208 (150–287) | 180 (127–484) | – |
| RBC (106/uL) | 4.5 ± 0.5 | 4.5 ± 0.6 | 3.6 ± 0.5 | 4.0 ± 0.6 | 1–3, 2–3 |
| MCV (fL) | 89.6 ± 4.5 | 90.0 ± 4.0 | 92.2 ± 5.3 | 91.1 ± 6.9 | – |
| MCH (pg) | 30.2 ± 1.7 | 30.3 ± 1.1 | 30.1 ± 1.3 | 30.1 ± 2.8 | – |
| MCHC (g/dL) | 34 (32–37) | 34 (33–36) | 33 (30–35) | 33 (30–35) | 2–4 |
| RDW (%) | 13.7 (12.1–16.2) | 13.8 (13.1–14.9) | 13.7 (11.4–15.4) | 14.5 (13.8–19.5) | 1–4, 2–4, 3–4 |
| MPV (fL) | 11.0 ± 1.0 | 11.0 ± 1.1 | 11.1 ± 0.7 | 11.6 ± 1.4 | – |
| PDW (fL) | 13.6 (9.5–20.1) | 13.0 (10.4–16.7) | 13.4 (11.6–23.6) | 13.6 (11.6–23.6) | – |
| PCT (%) | 0.24 (0.07–0.44) | 0.25 (0.06–0.37) | 0.25 (0.18–0.31) | 0.23 (0.15–0.50) | – |
| P-LCR (%) | 33.2 ± 8.2 | 33.3 ± 8.3 | 33.7 ± 5.7 | 38.0 ± 11.0 | – |
| CRP (mg/L) | 2.0 (0.5–30.0) | 2.6 (1.6–36.0) | 3.1 (1.0–19.0) | 6.0 (1.0–36.0) | 1–4 |
| Albumin (g/dL) | 3.82 (3.22–4.60) | 3.98 (3.30–4.58) | 3.88 (2.62–4.12) | 3.77 (2.75–4.68) | – |
CKD chronic kidney disease, LVDD left ventricular diastolic dysfunction, BMI body mass index, eGFR estimated glomerular filtration rate, PTH parathormone, NT-proBNP N-terminal pro brain natriuretic peptide, Hb hemoglobin concentration, HT hematocrit, PLT platelets, RBC red blood cells, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, RDW red cell distribution width, MPV mean platelet volume, PDW platelet distribution width, PCT plateletcrit, P-LCR platelet-large cell ratio, CRP C-reactive protein, 1 Early stage CKD without LVDD, 2 Early stage CKD with LVDD, 3 Advanced stage CKD without LVDD, 4 Advanced stage CKD with LVDD