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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Mol Cancer Res. 2015 May 20;13(8):1238–1247. doi: 10.1158/1541-7786.MCR-14-0674-T

Figure 6. Knockdown of CUL3 and PTEN results in decreased levels of superoxide.

Figure 6

Knockdown of CUL3 and/or PTEN in A549 cells results in reduced superoxide production. Representative brightfield (left) and red fluorescent (right, converted to grayscale) images of (A, B) A549 control cells and (C,D) A549 CUL3/PTEN knockdown cells treated with MitoSox. E) Graph of average MitoSox fluorescence/field of view/cell comparing control cells to PTEN, CUL3, and CUL3/PTEN knockdown A549 cells.